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Early Recurrence Patterns Following Totally Intracorporeal Robot-assisted Radical Cystectomy: Results from the EAU Robotic Urology Section (ERUS) Scientific Working Group

  • Justin W. Collins 1,
  • Abolfazl Hosseini 1,
  • Christofer Adding 1,
  • Tommy Nyberg 2,
  • Anthony Koupparis 3,
  • Edward Rowe 3,
  • Matthew Perry 4,
  • Rami Issa 4,
  • Martin C. Schumacher 5,
  • Carl Wijburg 6,
  • Abdullah E. Canda 7,
  • Melvin D. Balbay 8,
  • Karel Decaestecker 9,
  • Christian Schwentner 9,
  • Arnulf Stenzl 9,
  • Sebastian Edeling 11,
  • Saša Pokupić 11,
  • Fredrik D’Hondt 9,
  • Alexander Mottrie 9,
  • Peter N. Wiklund 1
1 Karolinska University Hospital, Stockholm, Sweden 2 Karolinska Institute, Stockholm, Sweden 3 Bristol Urological Institution, Bristol, UK 4 St. Georges Hospital London, London, UK 5 Hirslanden Klinik, Aarau, Switzerland 6 Carl Wijburg, Rijnstate, Arnhem, The Netherlands 7 Ankara Ataturk Hospital, Ankara, Turkey 8 Memorial Sisli Hospital, Istanbul, Turkey 9 Ghent University Hospital, Ghent, Belgium 10 University of Tübingen, Tübingen, Germany 11 Da Vinci Zentrum, Hanover, Germany 12 O.L.V, Clinic, Aalst, Belgium

Take home message

This multi-institutional series analyses early recurrence patterns among patients undergoing robot-assisted radical cystectomy for bladder cancer. No unusual recurrence patterns were identified. Early recurrence rates and locations appear similar to those for open series. Pathologic staging and lymph node status were associated with recurrences.

Publication: European Urology, Volume 71, Issue 5, May 2017, Pages 723-726

PII: S0302-2838(16)30744-8

DOI: 10.1016/j.eururo.2016.10.030

Recurrence following radical cystectomy often occurs early, with >80% of recurrences occurring within the first 2 yr. Debate remains as to whether robot-assisted radical cystectomy (RARC) negatively impacts early recurrence patterns because of inadequate resection or pneumoperitoneum. We report early recurrence patterns among 717 patients who underwent RARC with intracorporeal urinary diversion at nine different institutions with a minimum follow-up of 12 mo. Clinical, pathologic, radiologic, and survival data at the latest follow-up were collected. Recurrence-free survival (RFS) estimates were generated using the Kaplan-Meier method, and Cox regression models were built to assess variables associated with recurrence. RFS at 3, 12, and 24 mo was 95.9%, 80.2%, and 74.6% respectively. Distant recurrences most frequently occurred in the bones, lungs, and liver, and pelvic lymph nodes were the commonest site of local recurrence. We identified five patients (0.7%) with peritoneal carcinomatosis and two patients (0.3%) with metastasis at the port site (wound site). We conclude that unusual recurrence patterns were not identified in this multi-institutional series and that recurrence patterns appear similar to those in open radical cystectomy series.

Patient summary

In this multi-institutional study, bladder cancer recurrences following robotic surgery are described. Early recurrence rates and locations appear to be similar to those for open radical cystectomy series.

Radical cystectomy with extended pelvic lymph node dissection (PLND) provides the best chance of long-term survival for clinically localised muscle-invasive bladder cancer and high-grade recurrent noninvasive disease [1]. However, curative surgery remains challenging, with recurrence rates of 30–40% reported within 5 yr of surgery [2]. Recurrences often occur early; more than 80% occur within the first 2 yr after surgery, with average presentation occurring 10–15 mo after radical cystectomy [3].

Debate remains as to whether minimally invasive surgery negatively impacts survival outcomes due to inadequate resection, suboptimal lymph node dissection, or alteration of recurrence patterns due to tumour seeding related to pneumoperitoneum or insufflation [4]. A recent single-centre study compared open radical cystectomy (ORC) with robot-assisted radical cystectomy (RARC) and reported a similar incidence of overall transitional cell carcinoma (TCC) recurrences, with a higher frequency of peritoneal carcinomatosis and extraperitoneal lymph node recurrences among patients undergoing RARC [4].

It is recognised in ORC series that early recurrence is an indicator of poor prognosis that correlates closely with 5-yr recurrence-free survival (RFS) and overall survival [5]. The current evidence for long-term outcomes following RARC shows acceptable oncologic outcomes comparable to open series [2]. A multicentre study analysing data for 702 RARC patients with a minimum of 5-yr follow-up (median 67 mo) reported 5-yr RFS of 67%.

In the European Association of Urology Robotic Urology Section (ERUS) Scientific Working Group database, 717 patients at nine different institutions were identified who underwent totally intracorporeal RARC between December 2003 and March 2015. The follow-up protocol comprised history, physical examination, urine cytology, and laboratory measurements according to EAU guidelines. Diagnostic imaging was routinely performed at 4–6 mo for the first year, and at least annually thereafter, or more frequently when clinically indicated. The median follow-up was 31 mo (interquartile range [IQR] 20–46).

Patient demographics and oncologic outcomes are summarised in Table 1. Thirty-four patients (4.8%) had a positive surgical margin (PSM), of whom 31 (4.4%) had pT3/T4 disease. Three patients (0.4%) with organ-confined disease had a PSM. The median yield for extended PLND was 18 (IQR 13–25). Kaplan-Meier estimates were created for local and distant recurrence sites (Table 2). RFS at 3, 12, and 24 mo was 95.9%, 80.2%, and 74.6% respectively (Supplementary Fig. 1). Univariable and multivariable Cox regression was used to estimate hazard ratios for predictors of RFS (Supplementary material).

Table 1

Patient demographics and oncologic outcomes


Variable Result
Patients (n) 717
Male/female (n) 78/22
Median age, yr (IQR) 68 (62–74)
ASA grade (n)
 1 17
 2 51
 3 31
 4 1
Median BMI, kg/m2 (IQR) 26 (23–28)
Median follow-up, mo (IQR) 31 (20–46)
Histology, n (%)
 Transitional cell carcinoma 680 (95.2)
 Squamous cell carcinoma 20 (2.8)
 Adenocarcinoma 9 (1.2)
 Neuroendocrine 2 (0.3)
 Small cell carcinoma 3 (0.4)
 Missing data 3
Preoperative staging, n (%)
 Carcinoma in situ 34 (4.8)
 Ta 25 (3.5)
 T1 154 (21.6)
 T2 370 (52.0)
 T3 76 (10.7)
 T4 19 (2.7)
 Non–transitional cell carcinoma 34 (4.8)
 Missing data 5
Received neoadjuvant chemotherapy, n (%) 176 (25.2)
 Missing data 19
Pathological stage (%)
 pT0 136 (19.1)
 pTis 76 (10.7)
 pTa 34 (4.8)
 pT1 72 (10.1)
 pT2 162 (22.7)
 pT3 163 (22.9)
 pT4 69 (9.7)
 Missing data 5
Soft tissue margin positive, n (%) 34 (4.8)
 Missing data 2
PLND template, n (%)
 No PLND 35 (5.1)
 Standard 144 (20.8)
 Extended PLND 518 (74.3)
 Missing 20
Pathologic nodal stage, n (%)
 Nx 35 (4.9)
 N0 548 (77.1)
 N1 58 (8.2)
 N2 70 (9.8)
 Missing 6

PLND = pelvic lymph node dissection.

Table 2

Kaplan-Meier estimates of frequency of recurrence by site


Estimated recurrence rate (%)
3 mo 12 mo 24 mo
Any recurrence 4.1 19.8 25.4
Local recurrence 1.8 8.2 10.7
 Cystectomy bed 0.7 2.8 3.4
 Distal ureteric 0.1 0.3 0.5
 Urethral 0.0 0.1 0.5
 Pelvic lymph nodes 1.0 5.3 7.2
Distant recurrences 3.0 13.9 17.8
 Lung 1.1 4.6 6.2
 Liver 0.8 4.1 5.5
 Bone 1.0 5.2 6.4
 Brain 0.1 0.6 1.0
 Adrenal 0.0 0.3 0.7
 Bowel 0.0 0.3 0.3
 Pancreas 0.0 0.1 0.1
 Extrapelvic lymph nodes 1.4 4.9 6.6
 Peritoneal carcinomatosis 0.3 0.7 0.7
 Port site 0.0 0.3 0.3
 Skin 0.0 0.1 0.1
 Muscle 0.0 0.2 0.2
Secondary urothelial cancer
 Upper urinary tract 0.0 0.3 0.3
Multiple recurrences 2.0 8.0 11.0

We observed early recurrences at any site in 4.1% of patients at 3 mo, 19.8% at 12 mo, and 25.4% at 24 mo, similar to rates seen in ORC series [5], [6], and [7]. Distant recurrences were most frequent in the bones, lungs, and liver, while local recurrences were most common in pelvic lymph nodes. This is consistent with recurrence patterns seen in ORC and in autopsy series [6] and [7]. Regarding unusual recurrence patterns [4], five patients (0.7%) had peritoneal carcinomatosis and two patients (0.3%) had metastasis at the port site (wound site), which are both of low incidence and consistent with published ORC series [7]. In a recent review, RFS rates at 2 yr after surgery ranged from 67% to 81% in RARC series [8], and studies highlighting unusual recurrence patterns as a possible indicator of a detrimental effect have not shown a higher incidence of recurrences compared to ORC performed in the same institution [4].

It has been found at autopsy that peritoneal carcinomatosis incidence is as high as 19% among bladder cancer patients, but importantly it is most frequently associated with extensive metastases at multiple sites [6]. Review of the patients in our series with peritoneal carcinomatosis and port-site metastasis revealed that all had high-grade urethelial cancer. Four of the five patients with peritoneal carcinomatosis presented with multiple metastases, and 80% had postoperative upstaging of disease from organ-confined to non–organ-confined disease on the pathologic specimen report; only one of these patients (20%) received neoadjuvant chemotherapy. These findings indicate that peritoneal carcinomatosis due to tumour seeding is related to tumour biology rather than the pneumoperitoneum or other effects of an RARC approach.

It is important to replicate the oncologic principles of open surgery during RARC. Indications and contraindications for totally intracorporeal RARC, along with the preoperative work-up, patient preparation, and a standardised RARC surgical technique with extended PLND template, have previously been described [9]. Accepted early indicators of oncologic efficacy include PSM rates and lymph node yields [1] and [3]. Our multi-institutional database shows respectable PSM rates of 4.8% and median extended PLND yields of 18, consistent with open series [8]. On multivariable analysis the risk of recurrence was associated with positive compared to negative lymph nodes (N1 vs N0: hazard ratio [HR] 3.6, p < 0.0001; N2 vs N0: HR 5.6, p < 0.0001) and with pathologic non–organ-confined compared to organ-confined disease (HR 3.8, p < 0.0001), and was negatively associated with pT0 compared to organ-confined disease (HR 0.3, p < 0.001). On univariable analysis, PSMs (HR 4.49, p < 0.0001), selection for ileal conduit urinary diversion versus neobladder (HR 1.88, p < 0.001), and female gender (HR 1.63, p < 0.01) were all associated with a higher risk of recurrence. Neobladder patients are generally younger with less advanced disease [9], and female gender has been identified in ORC as an independent adverse prognostic factor for both recurrence and progression of bladder cancer [10]. These findings are consistent with findings in large ORC series, giving a further indication that early recurrences following RARC are primarily related to tumour biology [2]. Limitations of this study include the retrospective review, patient selection bias, and inclusion of learning curves. Despite the inclusion of learning curves, 32.6% of RARC patients had pT3/4 disease and 18.0% had positive lymph nodes.

No unusual recurrence patterns after RARC were identified in this multi-institutional study. Early recurrence rates and sites of recurrence appear similar to those for ORC series. Indicators of oncologic efficacy, namely PSM rates and PLND yields, are comparable to ORC series. Positive lymph nodes, non–organ-confined disease, and PSMs were associated with early recurrences, indicating that early recurrences following RARC are primarily related to tumour biology and not the modality of surgical treatment. Histopathologic stage pT0 was a positive prognostic factor for favourable oncologic outcomes.

Author contributions: Justin W. Collins had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Collins, Hosseini, Adding, Wiklund.

Acquisition of data: Collins, Hosseini, Adding, Koupparis, Rowe, Perry, Issa, Schumacher, Wijburg, Canda, Balbay, Decaestecker, Schwentner, Stenzl, Edeling, Pokupić, D’Hondt, Mottrie, Wiklund.

Analysis and interpretation of data: Nyberg, Collins, Adding, Wiklund.

Drafting of the manuscript: Collins, Hosseini, Adding, Wiklund.

Critical revision of the manuscript for important intellectual content: Hosseini, Adding, Koupparis, Rowe, Perry, Issa, Schumacher, Wijburg, Canda, Balbay, Decaestecker, Schwentner, Stenzl, Edeling, Pokupić, D’Hondt, Mottrie, Wiklund.

Statistical analysis: Nyberg, Collins, Adding, Wiklund.

Obtaining funding: None.

Administrative, technical, or material support: Nyberg, Collins, Adding, Wiklund.

Supervision: Wiklund.

Other: None.

Financial disclosures: Justin W. Collins certifies that all conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/affiliation, grants or funding, consultancies, honoraria, stock ownership or options, expert testimony, royalties, or patents filed, received, or pending), are the following: None.

Funding/Support and role of the sponsor: None.

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Commented by Piotr Chlosta

Retrospective analysis of early recurrences in 717 patients undergoing totally intracorporeal robot-assisted radical cystectomy (RARC) in nine centers showed recurrence patterns similar to those reported for open radical cystectomy series.