UROONCO BCa associate editor Dr. Francesco Del Giudice interviews the chair and members of EAU MIBC Guidelines panel, Prof. Antoine van Der Heijden, Dr. Laura Mertens and Prof. Richard Cathomas. They discuss the 2026 key changes of the EAU Guidelines for MIBC, including expanded perioperative systemic treatments, integration of advanced imaging, and emerging biomarkers such as ctDNA. They also talk about radical cystectomy versus neoadjuvant therapy and bladder‑preserving strategies, careful patient selection and how multidisciplinary collaboration is critical to optimise outcomes.